Page number 2
MEETING THE CHALLENGE of Fresh Cow Clinical and Subclinical Hypocalcemia Normal fresh cow blood calcium levels (> 8.5 mg/ dl) are highly correlated to the key metabolic pa- rameters essential for optimal fresh cow health, milk production, reproduction and overall productive life. Typical fresh cow incidence of clinical hypocalcemia (milk fever) is 3-6%, while subclinical hypocalcemia affects 50% or more of mature cows. The effects of clinical hypocalcemia (CH) can be financially significant; however, subclinical hypocal- cemia (SCH) is even more costly because it affects a much higher percent of fresh cows. Due to its insidious nature, routinely diagnosing SCH and appropriately treating on an individual cow basis is largely impractical. Cascading Effects of Hypocalcemia DECREASED: • DMI • Immune Function • Body Condition • Muscle Function Hypocalcemia < 8.5 mg/dl Health issue Dystocia Ketosis Displaced Abomasum Retained Placenta Metritis Mastitis Cull Rate Relative Risk * 3-6 X 3-8 X 2-5 X 2-4 X 4-5 X 7-8 X 2-3 X DECREASED: • Milk Production • Reproduction • Efficiency • Productive Life • Profitability * Relative Risk data sourced from multiple scientific journal articles.
Page number 3
UNCOMPLICATED EXELLENCE X-Zelit® offers a unique approach that is both effective and easy to use: 1. A dd X-Zelit® to the Prefresh diet. 2. Binds dietary phosphorus and calcium. 3. Promotes activation of 1-25(OH)2 Vitamin D and potential deactivation of FGF-23 (Fibroid Growth Factor-23) via a novel P homeostasis pathway. 4. T riggers bone mobilization of Ca and P in preparation of calving. 5. Optimizes blood calcium levels at calving, which lowers risk of milk fewer and hypocalcemia increasing the opportunity for transition success. DELIVERING RESULTS Hassle-Free Blood Calcium Elevation Blood Calcium Levels 100 9.5 9.0 8.69 8.76 9 mg/dl 8.5 8.0 7.5 7.27 7.24 7.78 7.0 6.5 6.0 6 hrs 18 hrs 48 hrs Hours Post Calving Control Cornell University Study; Published in Journal of Dairy Science, 2019 9.45 8.4 72 hrs “ We ran (X-Zelit®) on a trial basis with some of our 2nd lactation cows… and saw our subclinical hypocalcemia go from 50% to 20%. After the trial results, we expanded X-Zelit’s use to all of our cows because of the reduction to subclinical hypocalcemia. – John Verwey, Johann Dairy, Fresno, CA, Milking 4,000 ”
