Table&of&contents& Table&of&contents& LIST OF STUDIES. 3! LIST OF ABBREVIATIONS . 4! 1. INTRODUCTION . 5! 1.1 ROUTINE MANAGEMENT OF DYSPNEA IN THE AMBULANCE . 5! 1.2 MANAGEMENT OF THE DYSPNEIC PATIENT BY CRITICAL CARE TEAM PHYSICIAN . 6! 1.3 POINT-OF-CARE DIAGNOSTICS . 6! 1.4 BRAIN NATRIURETIC PEPTIDES. 6! 1.5 BRAIN NATRIURETIC PEPTIDES AS A POINT- OF-CARE ANALYSIS . 7! 2 AIMS AND HYPOTHESES. 8! 2.1 AIMS . 8! 2.2 HYPOTHESES . 8! 3. METHODOLOGIES . 9! 3.1 STUDY OVERVIEW . 9! 3.2 SETTING . 9! 3.3 PART 1 – MORTALITY AND ETIOLOGY STUDIES.10! 3.3.1 Participants.10! 3.3.2 Data sources.10! 3.3.3 Register-based research .10! 3.3.4 Exposures and outcomes.10! 3.3.4 Confounder adjustment and Charlson Comorbidity Index .10! 3.3.6 Survival analysis, emergency medicine and non-proportional hazards.11! 3.4 - PART 2 – POINT-OF-CARE DIAGNOSTIC STUDY .12! 3.4.1 Participants.12! 3.4.2 Randomization and intervention .12! 3.4.3 Education .12! 3.4.4 Outcome measures .12! 3.4.5 Data collection.13! 3.4.6 End-point adjudication committee .13! 3.4.7 Statistical analysis .13! 3.5 GENERAL METHODOLOGICAL CONSIDERATIONS.13! 3.5.1 Missing data and sensitivity analyses.13! 3.5.2 Ethics .14! 4. RESULTS . 15! 4.1 PART 1 – MORTALITY AND ETIOLOGY.15! 4.1.1 Baseline characteristics .15! 4.1.2 Symptoms and mortality .15! 4.1.3 High risk groups based on AMI diagnosis and ECG interpretation .21! 4.1.4 High risk groups based on preexisting disease and subsequent diagnoses.21! 4.1.5 Sensitivity analysis.21! 4.2 PART 2 – POINT-OF-CARE DIAGNOSTICS .22! 4.2.1 Baseline characteristics .22! 4.2.2 Missing data on primary cause of dyspnea in the ambulance .22! 4.2.3 Endpoint adjudication .22! 4.2.4 Predefined outcome measures .24! 4.2.5 Diagnostic performance .24! 4.2.6 Sensitivity analyses .24! Dyspnea&in&the&ambulance&–&mortality,&etiology&and&point9of9care&diagnostics& 1&
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